December 1, 1995Journal of Clinical InvestigationOpen Access

Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

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Population

Lipoprotein lipase-deficient mice created by gene targeting in embryonic stem cells

Comparison

Total or partial LPL deficiency via gene… vs Wild-type control mice

Design

Preclinical

Follow-up

Approximately 18 hours for homozygous knockouts; adulthood…

Authors

PWPeter WeinstockBoston Children's Hospital CBC L BisgaierHouston Methodist KAKatriina Aalto‐SetäläElectrophysiology

Discussion

Member takes

Implication

Preclinical LPL knockout data warrant no clinical practice change; leaves open tissue-targeted therapy potential in humans.

Structured PICO

Population

Lipoprotein lipase (LPL)-deficient mice created by gene targeting in embryonic stem cells (homozygous knockout, heterozygous, and transgenic rescue lines)

Intervention

Total or partial LPL deficiency via gene knockout, and muscle-specific human LPL expression

Comparator

Wild-type control mice

Outcome

Survival and triglyceride levelssurrogate

Total LPL deficiency in mice causes fatal neonatal hypertriglyceridemia that can be rescued by muscle-specific LPL expression, while partial deficiency causes mild hypertriglyceridemia and impaired VLDL clearance.

Cite This Study

Weinstock et al. (1995) studied this question.

synapsesocial.com/papers/69d978c80d540cafc58358bb https://doi.org/10.1172/jci118319

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Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider