March 21, 2017JAMA200 citationsOpen Access
Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation
Structured PICO
Does dabigatran reduce the risk of osteoporotic fractures compared to warfarin in adults with nonvalvular atrial fibrillation?
P
Population
Adults with nonvalvular atrial fibrillation (NVAF) receiving anticoagulation
I
Intervention
Dabigatran
C
Comparator
Warfarin
O
Outcome
Risk of osteoporotic fractureshard clinical
Dabigatran is associated with a lower risk of osteoporotic fractures compared to warfarin in patients with nonvalvular atrial fibrillation.
Abstract
Among adults with NVAF receiving anticoagulation, the use of dabigatran compared with warfarin was associated with a lower risk of osteoporotic fracture. Additional study, perhaps including randomized clinical trials, may be warranted to further understand the relationship between use of dabigatran vs warfarin and risk of fracture.