What question did this study set out to answer?

To review the classification, activation mechanisms, and distinct physiological roles of the small GTP-binding protein superfamily in eukaryotic cells.

January 1, 2001Physiological Reviews

Small GTP-Binding Proteins

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Authors

YTYoshimi TakaiKanazawa University TSTakuya SasakiNagoya University TMTakashi MatozakiKobe University

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Implication

Review outlines the regulation of temporal and spatial cellular activities by small G proteins in eukaryotes, highlighting their conserved roles as molecular switches.

Key Points

To review the classification, activation mechanisms, and distinct physiological roles of the small GTP-binding protein superfamily in eukaryotic cells.
Narrative synthesis of structural and biochemical findings across more than 100 members of the small G protein superfamily.
Evaluation of upstream regulators, downstream effectors, and signaling cascades across eukaryotic models from yeast to humans.
Identified five core structural families functioning as spatial and temporal biological timers: Ras (gene expression), Rho (cytoskeleton and gene expression), Rab and Sar1/Arf (vesicle trafficking), and Ran (nucleocytoplasmic transport and microtubules).
Characterized the regulatory modes and downstream effector pathways that coordinate cross-talk and activation cascades to maintain cellular homeostasis.

Cite This Study

Takai et al. (2001) studied this question.

synapsesocial.com/papers/69d97d042a25b240b7a3c8d1 https://doi.org/10.1152/physrev.2001.81.1.153

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Implication

Review outlines the regulation of temporal and spatial cellular activities by small G proteins in eukaryotes, highlighting their conserved roles as molecular switches.

Small GTP-Binding Proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

Small GTP-Binding Proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

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