What question did this study set out to answer?

To investigate the therapeutic effects and molecular mechanisms of the Ciji-Hua'ai-Baosheng II Formula on chemotherapy-induced anorexia in a murine model of H22 hepatocellular carcinoma.

August 19, 2021SHILAP Revista de lepidopterologíaOpen Access

The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma

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Authors

SXShengyan XiSun Yat-sen University XZXiangyang ZhaiWenzhou Medical University YWYanan WangSouthwest University of Science and Technology

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Implication

Animal study demonstrates that Ciji-Hua'ai-Baosheng II formula alleviates 5-fluorouracil-induced anorexia in mice with liver cancer, suggesting restored central and peripheral appetite regulation.

Key Points

To investigate the therapeutic effects and molecular mechanisms of the Ciji-Hua'ai-Baosheng II Formula on chemotherapy-induced anorexia in a murine model of H22 hepatocellular carcinoma.
Inoculated 72 Kunming mice with H22 hepatoma cells and administered 200 mg/kg 5-fluorouracil intraperitoneally after one week to establish chemotherapy-induced toxicity.
Randomized mice into six groups treated for 14 days: untreated, 5-FU alone, 5-FU plus Yangzheng Xiaoji capsule, and 5-FU plus low-, medium-, or high-dose CHB-II-F.
Assessed tumor inhibition, body weight, food consumption, gut histopathology, circulating gastrointestinal hormones, jejunal oxidative stress markers, and hypothalamic appetite-regulating genes and proteins.
Tumor inhibition rates were 58.88% for 5-FU alone, 54.96% for high-dose CHB-II-F, 37.69% for medium-dose, 28.61% for low-dose, and 28.08% for the positive control YZXJC group.
CHB-II-F significantly increased body weight, food intake, serum NPY, orexin A, ghrelin, gastrin, motilin, and jejunal SOD activity, while reducing serum leptin and jejunal MDA compared to the 5-FU group.
CHB-II-F upregulated hypothalamic protein and mRNA levels of OX1R, GHSR, NPY, and AgRP, while downregulating Ob-R, POMC, CART, and duodenal 5-HT and substance P.

Cite This Study

Xi et al. (2021) studied this question.

synapsesocial.com/papers/69d97f65387cf70698684575 https://doi.org/10.3389/fphar.2021.715824

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Implication

Animal study demonstrates that Ciji-Hua'ai-Baosheng II formula alleviates 5-fluorouracil-induced anorexia in mice with liver cancer, suggesting restored central and peripheral appetite regulation.

The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma

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Cite This Study

The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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