Key result
Greater hypertrophy and absent outflow obstruction link to worse prognosis in feline HCM.
Why the study?
A spontaneously occurring disease of domestic cats similar to human HCM was identified, but its echocardiographic characteristics and prognostic factors needed description.
Observational
Feline HCM shares phenotypic similarities with human HCM and may serve as a valuable animal model for the disease.
Greater hypertrophy without obstruction signals poor feline prognosis; leaves open extension to human HCM models.
A spontaneously occurring disease of domestic cats was identified by echocardiography and was similar in its phenotypic expression to HCM in humans; it was characterized by unexplained left ventricular hypertrophy in a variety of patterns with or without evidence of outflow obstruction. Unfavorable prognosis was associated with greater magnitude of hypertrophy and absence of outflow obstruction. Feline HCM may prove to be a valuable animal model of the human disease.
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Fox et al. (1995) conducted an observational in Feline Hypertrophic Cardiomyopathy. Feline Hypertrophic Cardiomyopathy was evaluated on Prognosis. In domestic cats with spontaneously occurring hypertrophic cardiomyopathy, an unfavorable prognosis was associated with greater magnitude of hypertrophy and absence of outflow obstruction.
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