Key result
Feline hypertrophic cardiomyopathy serves as a valuable, naturally occurring large animal model that is genotypically and phenotypically similar to human HCM, offering opportunities to accelerate translational research.
Naturally occurring feline hypertrophic cardiomyopathy closely mimics human HCM and provides an excellent translational model to bridge the gap between rodent studies and human clinical trials.
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Supports feline HCM modeling for preclinical studies; leaves open translation to human therapies without validation.
Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an excellent natural model that is genotypically and phenotypically similar to human HCM. The Maine Coon and Ragdoll cats are particularly valuable models of HCM because of myosin binding protein-C mutations and even higher disease incidence compared to the overall feline population. The cat overcomes many of the limitations of rodent HCM models, and can provide enhanced translation of information from in vitro and induced small animal models to human clinical trials. Physicians and veterinarians working together in a collaborative and interdisciplinary approach can accelerate the discovery of more effective treatments for this and other cardiovascular diseases affecting human and veterinary patients. Cardiol Res. 2017;8(4):139-142 doi: https://doi.org/10.14740/cr578w
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Freeman et al. (2017) conducted a review in Hypertrophic cardiomyopathy. Feline hypertrophic cardiomyopathy serves as a valuable, naturally occurring large animal model that is genotypically and phenotypically similar to human HCM, offering opportunities to accelerate translational research.
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