What question did this study set out to answer?

September 17, 2000Journal of Clinical OncologyOpen Access

Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study

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Authors

HMHans von der MaaseUniversity of Copenhagen SHSteen Werner HansenAarhus University Hospital JRJ.T. RobertsTufts University

Discussion

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Implication

Randomized trial demonstrates equivalent survival and improved tolerability with gemcitabine and cisplatin versus MVAC in advanced bladder cancer, supporting a new standard of care.

Key Points

Compare the efficacy, tolerability, and safety of gemcitabine plus cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in patients with advanced or metastatic transitional cell carcinoma.
Multinational, multicenter, randomized phase III clinical trial.
Evaluated patients with locally advanced or metastatic transitional cell carcinoma receiving either gemcitabine plus cisplatin or standard MVAC chemotherapy.
Gemcitabine plus cisplatin demonstrated an overall survival outcome comparable to that of standard MVAC therapy.
Gemcitabine plus cisplatin provided a superior safety profile with significantly improved treatment tolerability relative to MVAC.

Cite This Study

Maase et al. (2000) studied this question.

synapsesocial.com/papers/69d9845c5e5bcb4e3b836e80 https://doi.org/10.1200/jco.2000.18.17.3068

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Implication

Randomized trial demonstrates equivalent survival and improved tolerability with gemcitabine and cisplatin versus MVAC in advanced bladder cancer, supporting a new standard of care.

Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study

Discussion

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Implication

Key Points

Cite This Study

Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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