Case series uncovers distinct high-titer CASPR2 and LGI1 antibodies in Morvan syndrome, indicating widespread neural binding accounts for multifocal symptoms.
MoS is clinically distinct from other VGKC-complex antibody-associated conditions, and usually is associated with high-titer CASPR2 antibodies, often accompanied by lower-titer LGI1 antibodies. CASPR2 and LGI1 antibodies bind to multiple brain regions, which helps to explain the multifocal clinical features of this disease, but other antibodies are likely to play a role in some patients and need to be characterized in future studies.
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Irani et al. (2012) studied this question.
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