Why the study?
What are the pharmacokinetics of sacubitril/valsartan, and is it safe and effective in maintenance hemodialysis patients with heart failure?
What are the pharmacokinetics of sacubitril/valsartan, and is it safe and effective in maintenance hemodialysis patients with heart failure?
Sacubitril/valsartan 100 mg BID appears safe and effective in hemodialysis patients with heart failure, despite hemodialysis not removing its active metabolites.
May support sacubitril/valsartan in hemodialysis heart failure; leaves open randomized confirmation.
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Feng et al. (2021) studied this question.
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