Periprostatic adipose tissue may modulate prostate cancer aggressiveness by serving as a source of interleukin-6, which activates STAT3 signaling.
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Periprostatic adipose IL-6/STAT3 signaling may influence prostate cancer aggressiveness; this animal finding leaves open its relevance in patients.
Higher Gleason score correlated with high levels of conditioned medium derived interleukin-6. Moreover, cell signaling analysis of periprostatic adipose tissue identified activated signaling molecules, including STAT3, that correlated with Gleason score. Since STAT3 is interleukin-6 regulated, these findings suggest that periprostatic adipose tissue may have a role in modulating prostate cancer aggressiveness by serving as a source of interleukin-6. Also, we found low numbers of inflammatory cells in the fat, suggesting that adipocytes are the major secretors of interleukin-6.
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Finley et al. (2009) studied this question.
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