Key result
Specific omental adipose insulin signaling derangements accurately discriminate NASH from non-progressive NAFLD.
Why the study?
Omental adipose tissue may play a role in the development and progression of NAFLD, but its specific signaling alterations are not well characterized.
Observational (n=99)
Specific insulin pathway signaling events are altered in the omental adipose tissue of patients with NASH, suggesting a role for omental fat in NAFLD pathogenesis and progression.
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May distinguish NASH via omental signaling; leaves open causal role and clinical utility.
Calvert et al. (2007) conducted an observational in Nonalcoholic fatty liver disease (NAFLD) (n=99). Nonalcoholic steatohepatitis (NASH) vs. Non-progressive forms of NAFLD was evaluated on Intracellular signaling pathway derangement in omental adipose tissue. Specific insulin pathway signaling events in omental adipose tissue, including PKA and AKT/mTOR derangement, accurately discriminate patients with NASH from those with non-progressive NAFLD.
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