December 16, 1986Biochemistry

Molecular cloning of three distinct forms of the Na+,K+-ATPase .alpha.-subunit from rat brain

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Population

Rat brain and kidney cDNA libraries

Design

Preclinical

Authors

GSGary E. ShullElectrophysiology JGJ GreebUniversity of Cincinnati Medical Center JLJerry B. LingrelUniversity of Cincinnati Medical Center

Discussion

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Implication

Novel alpha III isoform in rat brain suggests tissue-specific glycoside sensitivity; leaves open human cardiac translation and therapeutic targeting.

Structured PICO

Population

Rat brain and kidney cDNA libraries

Intervention

Molecular cloning and sequencing

Outcome

Identification and sequencing of Na+,K+-ATPase alpha-subunit isoforms

The study identifies three distinct isoforms of the Na+,K+-ATPase alpha-subunit in rat brain, including a novel alpha III isoform, providing molecular insights into tissue-specific cardiac glycoside sensitivity.

Cite This Study

Shull et al. (1986) studied this question.

synapsesocial.com/papers/69d98f495e5bcb4e3b837073 https://doi.org/10.1021/bi00373a001

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Implication

Novel alpha III isoform in rat brain suggests tissue-specific glycoside sensitivity; leaves open human cardiac translation and therapeutic targeting.

Molecular cloning of three distinct forms of the Na+,K+-ATPase .alpha.-subunit from rat brain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular cloning of three distinct forms of the Na+,K+-ATPase .alpha.-subunit from rat brain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider