Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population

Tetsuya Kawahara; Gen Suzuki; Shoichi Mizuno; Tetsuya Inazu; Fumiyoshi Kasagi; Chie Kawahara; Yosuke Okada; Yoshiya Tanaka

doi:10.1136/bmj-2021-066222

May 25, 2022BMJOpen Access

Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population

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Key Points

To determine whether intervention with active vitamin D prevents or delays the onset of type 2 diabetes in high-risk individuals in Japan.
Conducted a randomized controlled trial (DPVD trial, registered with the UMIN Clinical Trials Registry as UMIN000010758) in Japan.
Assigned participants to receive active vitamin D therapy versus control to monitor diabetes incidence.
Evaluated primary incidence rates of type 2 diabetes conversion between treatment arms under trial registry protocol UMIN000010758.
Tracked longitudinal glycemic status, beta-cell function, and metabolic parameters under active vitamin D therapy.

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Implication

Randomized trial reports the effect of active vitamin D on type 2 diabetes onset in a Japanese cohort, suggesting potential targeted preventive strategies.

Abstract

UMIN Clinical Trials Registry UMIN000010758.

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Cite This Study

Kawahara et al. (2022) studied this question.

synapsesocial.com/papers/69d994d18d5c517421a3bf95 https://doi.org/10.1136/bmj-2021-066222

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Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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