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Prospective cohort study shows an L-shaped link between serum vitamin D and mortality in osteoarthritis patients, highlighting potential thresholds for risk reduction.
Nonlinear associations of serum 25(OH)D levels with all-cause and CVD mortality were observed in American patients with OA. The thresholds of 27.70 and 54.40 nmol/L for CVD and all-cause mortality, respectively, may represent intervention targets for lowering the risk of premature death and cardiovascular disease, but this needs to be confirmed in large clinical trials.
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Xiao et al. (2022) studied this question.
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