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June 9, 2011Journal of NeurophysiologyOpen Access

The organization of the human cerebral cortex estimated by intrinsic functional connectivity

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Authors

BYB.T. Thomas YeoUniversity of TsukubaFKFenna M. KrienenBroad InstituteJSJorge SepulcreYale University

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Implication

Functional neuroimaging study reveals distinct local sensory and distributed association networks in 1,000 human subjects, suggesting parallel interdigitated circuits underlying advanced cognition.

Key Points

  • To characterize the large-scale functional organization of the human cerebral cortex using intrinsic resting-state functional connectivity MRI.
  • Acquired resting-state functional connectivity MRI data from 1,000 healthy human subjects aligned to a common surface-based coordinate system.
  • Implemented a clustering algorithm across the cortical surface to discover and validate functionally coupled networks spanning sensory, motor, and association regions.
  • Identified local networks confined to sensory and motor cortices displaying topographic organization, contrasted with distributed association networks featuring sharp functional boundaries.
  • Hierarchical connectivity was demonstrated across adjacent subregions of the MT+ complex within a canonical sensory-motor pathway.
  • Parietal and prefrontal association cortices exhibited distinct connectivity profiles consistent with parallel, interdigitated circuits rather than strictly hierarchical schemes.

Cite This Study

Yeo et al. (2011) studied this question.

synapsesocial.com/papers/69d99bc72a25b240b7a3d094https://doi.org/10.1152/jn.00338.2011
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