Identifies exosomal miR-342-5p from long-term exercise as a novel endogenous cardioprotective mechanism against ischemia/reperfusion injury.
Cautious extrapolation to patients advised; leaves open whether exosomal miR-342-5p mediates exercise cardioprotection in humans.
Our findings reveal a novel endogenous cardioprotective mechanism that long-term exercise-derived circulating exosomes protect the heart against myocardial ischemia/reperfusion injury via exosomal miR-342-5p.
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Hou et al. (2019) studied this question.
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