The Enzymatic Asymmetric Conjugate Umpolung Reaction

The Stetter reaction employs synthetically useful umpolung reactivity to provide catalytic access to 1,4-bifunctional molecules. The first enzymatic 1,4-addition is described, with the ThDP-dependent enzyme PigD, which makes the challenging asymmetric intermolecular Stetter reaction accessible. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.