Does conditional heterozygous or homozygous Bmpr2 deletion in pulmonary endothelial cells predispose mice to develop pulmonary arterial hypertension?
Genetic ablation of the Bmpr2 gene specifically in pulmonary endothelial cells is sufficient to predispose mice to pulmonary arterial hypertension.
Conditional heterozygous or homozygous Bmpr2 deletion in pulmonary endothelial cells predisposes mice to develop PAH.
Hong et al. (Tue,) studied this question.