Estrogen contributes to gender differences in ventricular repolarization in mice via downregulation of specific potassium channel transcripts.
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Does not inform clinical arrhythmia management; leaves open translation of estrogen-Kv channel effects from mice to humans.
Downregulation of Kv4.3 and Kv1.5 transcripts by estrogen are one mechanism defining gender-related differences in mouse ventricular repolarization.
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Saito et al. (2009) studied this question.
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