Why the study?
Does pregnancy or estrogen treatment induce specific molecular and functional changes related to physiological heart hypertrophy in mice?
Does pregnancy or estrogen treatment induce specific molecular and functional changes related to physiological heart hypertrophy in mice?
Pregnancy-related physiological heart hypertrophy in mice is associated with estrogen-induced downregulation of Kv4.3 channels and increased c-Src activity, providing a molecular basis for prolonged QT intervals during pregnancy.
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May explain gestational QT prolongation in mice; hypothesis-generating for human arrhythmia mechanisms.
Eghbali et al. (2005) studied this question.
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