Key result
Pregnancy attenuates pathological LV remodeling and pulmonary congestion following transverse aortic constriction in mice.
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No immediate clinical implications for peripartum cardiomyopathy; leaves open translation of murine TAC protection to human HF.
Xu et al. (2016) studied Left ventricular pressure overload. Pregnancy vs. Non-pregnant mice with TAC was evaluated on Maternal cardiac structure and function, ability to conceive, and pregnancy outcome. Pregnancy attenuated pathological left ventricular remodeling, mitigated pulmonary congestion, and reduced pathological gene expression produced by transverse aortic constriction in mice.
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