Population
Adult female Sprague-Dawley rats divided into nonpregnant, 18 days pregnant, 0 days postpartum, and 14 days…
Comparison
Pregnancy and postpartum states vs Nonpregnant state
Design
Preclinical
Follow-up
Up to 14 days postpartum
Authors
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Alerts to delayed postpartum EF recovery in physiological hypertrophy models; leaves open JNK dysregulation as a mechanism in peripartum cardiomyopathy.
Pregnancy induces physiological cardiac hypertrophy that rapidly reverses postpartum, but delayed recovery of cardiac function may be driven by dysregulation of MAPK signaling, particularly JNK upregulation.
González et al. (2007) studied this question.
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