Key result
Inhibition of the NRG1/ErbB system with lapatinib during pregnancy led to premature maternal death of ~25%, accentuated LV dilatation, and reduced LV fractional shortening in rats and mice.
Why the study?
Does inhibition of the NRG1/ErbB system with lapatinib impair left ventricular performance during physiological hemodynamic overload in pregnant rats and mice?
Does inhibition of the NRG1/ErbB system with lapatinib impair left ventricular performance during physiological hemodynamic overload in pregnant rats and mice?
The NRG1/ErbB system is activated and plays a crucial modulatory role during physiological hemodynamic overload in pregnancy, and its inhibition can cause significant LV dysfunction and maternal mortality.
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NRG1/ErbB activation may aid LV adaptation in gestational overload; leaves open therapeutic relevance in peripartum cardiomyopathy.
Lemmens et al. (2010) studied Physiological ventricular remodeling in pregnancy. Lapatinib vs. Untreated/control was evaluated on Premature maternal death. Inhibition of the NRG1/ErbB system with lapatinib during pregnancy led to premature maternal death of ~25%, accentuated LV dilatation, and reduced LV fractional shortening in rats and mice.
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