Why the study?
Does neuregulin-1 induce a negative inotropic effect in isolated rabbit papillary muscles and cultured rat cardiomyocytes?
Population
Isolated rabbit papillary muscles and cultured rat cardiomyocytes
Design
Preclinical
Authors
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NRG-1 may blunt contractility and beta-adrenergic responses in animal cardiac muscle; leaves open human relevance and therapeutic implications.
Does neuregulin-1 induce a negative inotropic effect in isolated rabbit papillary muscles and cultured rat cardiomyocytes?
Neuregulin-1 induces a negative inotropic effect in cardiac muscle, likely mediated by the activation of endothelial nitric oxide synthase.
Lemmens et al. (2004) studied this question.
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