Does progesterone modulate cardiac repolarization?
Progesterone regulates cardiac repolarization via a nongenomic nitric oxide pathway, providing a framework to understand QT interval fluctuations and torsade de pointes risks in different hormonal states in women.
Our data show that progesterone modulates cardiac repolarization by nitric oxide produced via a nongenomic pathway. A combination of experimental and computational analyses of progesterone effects provides a framework to understand complex fluctuations of QT interval and torsade de pointes risks in various hormonal states in women.
Nakamura et al. (Tue,) studied this question.