Key result
Ibutilide-induced QTc prolongation was significantly greater in women during menses (63 ms) and ovulation (59 ms) compared to men (46 ms; P=0.002 and P=0.007, respectively).
Why the study?
Does the degree of drug-induced QT prolongation from ibutilide vary with the menstrual cycle phase in women compared to men?
Population
58 healthy adults (38 men and 20 women) aged 21 to 40 years.
Comparison
Ibutilide 0.003 mg/kg infused intravenously for… vs Men receiving the same intervention, and…
Design
Cohort
Follow-up
120 minutes
Authors
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May heighten ibutilide QTc risk during early cycle phases in women; hypothesis-generating and should not yet change practice.
Cohort (n=58)
No
Does the degree of drug-induced QT prolongation from ibutilide vary with the menstrual cycle phase in women compared to men?
Absolute Event Rate: 63% vs 46%
p-value: p=0.002
Drug-induced QT prolongation is greatest during the first half of the menstrual cycle (menses and ovulation) in women compared to the luteal phase and to men.
Ignacio Rodríguez (2001) conducted a cohort in Healthy adults (n=58). Ibutilide vs. Men and different menstrual cycle phases was evaluated on Maximum increase in QTc interval (p=0.002). Ibutilide-induced QTc prolongation was significantly greater in women during menses (63 ms) and ovulation (59 ms) compared to men (46 ms; P=0.002 and P=0.007, respectively).
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