Why the study?
Does female gender increase the risk of ibutilide-induced QT prolongation and torsades de pointes in a rabbit model of acquired long QT syndrome?
Population
80 New Zealand White rabbits, divided into young and adult, anesthetized with alpha-chloralose and…
Comparison
Ibutilide infusion at 8 nmol/kg/min for maximum… vs Ibutilide infusion at 8 nmol/kg/min for maximum…
Design
Preclinical
Follow-up
up to 30 minutes
Authors
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No gender difference in ibutilide-induced TdP in rabbits; hypothesis-generating and should not inform human risk stratification.
Does female gender increase the risk of ibutilide-induced QT prolongation and torsades de pointes in a rabbit model of acquired long QT syndrome?
In an in vivo rabbit model of acquired long QT syndrome, female gender was not associated with greater QT prolongation or a higher incidence of torsades de pointes in response to ibutilide compared to males.
Johansson et al. (2001) studied this question.
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