Key result
Quinidine administration resulted in a 44% greater QTc interval prolongation relative to serum concentration in women compared to men (42.2 vs 29.3 ms/microg per mL, P<0.001).
Why the study?
Does a single intravenous dose of quinidine cause greater QTc interval prolongation in healthy young women compared to men?
Population
24 healthy young adults (12 women and 12 men)
Comparison
Single intravenous dose of quinidine (4 mg/kg) vs Placebo (crossover design)
Design
RCT, randomized crossover trial, single-blind
Authors
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Heightened QT monitoring warranted in women on quinidine; confirms greater female susceptibility to drug-induced torsades.
RCT (n=24)
Single-blind
crossover
Does a single intravenous dose of quinidine cause greater QTc interval prolongation in healthy young women compared to men?
Effect estimate: 44% greater
Absolute Event Rate: 42.2% vs 29.3%
p-value: p=<.001
Quinidine causes significantly greater QTc prolongation in women than in men at equivalent serum concentrations, which may explain the higher risk of drug-induced torsades de pointes in women.
R.E. Benton (2000) conducted an RCT in Healthy (n=24). quinidine vs. placebo was evaluated on slope of the relationship between change in the QTc interval from baseline to the serum concentration of quinidine (44% greater, p=<.001). Quinidine administration resulted in a 44% greater QTc interval prolongation relative to serum concentration in women compared to men (42.2 vs 29.3 ms/microg per mL, P<0.001).
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