What question did this study set out to answer?

To review the role of the interleukin-3 receptor alpha-chain (CD123) as an overexpressed membrane biomarker and potential therapeutic target across various hematologic malignancies.

February 10, 2014Biomarker ResearchOpen Access

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

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Authors

UTUgo TestaIstituto Superiore di Sanità EPElvira PelosiIstituto Superiore di Sanità AFArthur E. FrankelTexas A&M Health Science Center

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Implication

Review reveals CD123 overexpression across diverse hematologic malignancies, indicating its viability as a selective target for targeted therapeutics.

Key Points

To review the role of the interleukin-3 receptor alpha-chain (CD123) as an overexpressed membrane biomarker and potential therapeutic target across various hematologic malignancies.
Literature review analyzing preclinical and clinical studies evaluating CD123 expression and therapeutic targeting in leukemic disorders.
Evaluation of targeted strategies including interleukin-3 natural ligand conjugates and neutralizing monoclonal antibodies.
CD123 shows elevated expression in acute myeloid leukemia, B-lymphoid leukemias, blastic plasmacytoid dendritic cell neoplasms (BPDCN), and hairy cell leukemia, while maintaining low or absent expression on normal hematopoietic stem cells.
Fusion molecules comprising human interleukin-3 coupled to truncated diphtheria toxin exhibit promising antitumor activity in patients with BPDCN and acute myeloid leukemia.

Cite This Study

Testa et al. (2014) studied this question.

synapsesocial.com/papers/69d9a74f7f18ff2fefa3c35d https://doi.org/10.1186/2050-7771-2-4

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Implication

Review reveals CD123 overexpression across diverse hematologic malignancies, indicating its viability as a selective target for targeted therapeutics.

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

Discussion

Member takes

Implication

Key Points

Cite This Study

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

Discussion

Member takes

Implication

Key Points

Cite This Study

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