Is higher aPTT associated with an increased risk of bleeding events in adults undergoing extracorporeal membrane oxygenation?
In adults undergoing ECMO, bleeding events are highly prevalent (>60%) and associated with hospital mortality, with higher aPTT identified as an independent risk factor.
Bleeding events based on the ELSO bleeding definition occurred in more than 60 % of ECMO episodes and were associated with hospital mortality. We identified higher aPTT prior bleeding as an independent risk factor for bleeding event, suggesting that better control of the aPTT (through a better control of either coagulopathy or anticoagulation) may improve patients' outcome.
Aubron et al. (Thu,) studied this question.