Why the study?
Is higher aPTT associated with an increased risk of bleeding events in adults undergoing extracorporeal membrane oxygenation?
Is higher aPTT associated with an increased risk of bleeding events in adults undergoing extracorporeal membrane oxygenation?
In adults undergoing ECMO, bleeding events are highly prevalent (>60%) and associated with hospital mortality, with higher aPTT identified as an independent risk factor.
Bleeding events based on the ELSO bleeding definition occurred in more than 60 % of ECMO episodes and were associated with hospital mortality. We identified higher aPTT prior bleeding as an independent risk factor for bleeding event, suggesting that better control of the aPTT (through a better control of either coagulopathy or anticoagulation) may improve patients' outcome.
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Aubron et al. (2016) studied this question.
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