Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy

This is the authors' abstract. We don't add key points for this paper.

In doing so, we detail its maturation as a diagnostic marker through describing the development of CtsB-specific Activity-Based Probes, the rapid evolution of these toward a new generation of Prodrugs, and the evaluation of these in model systems for their therapeutic potential as anti-cancer agents in the clinic.