Does perioperative esketamine reduce the risk of perioperative neurocognitive disorders in adult patients?
Perioperative esketamine may reduce the risk of perioperative neurocognitive disorders in adults, though current evidence is limited by low certainty and short follow-up.
Perioperative esketamine is potentially effective in reducing the risk of POND and improving cognitive function in adult patients, regardless of age and dosage. Nevertheless, the certainty of evidence was low to very low for several outcomes (e.g., cognitive function on POD 3). Given that all included studies were conducted in China with relatively short follow-up periods, further high-quality RCTs with diverse populations and longer follow-up are warranted to validate these findings.
Hung et al. (Sat,) studied this question.