What question did this study set out to answer?

To assess whether genetically determined circulating levels of cytokines, particularly MCP-1, are causally linked to the risk of stroke and specific stroke subtypes.

January 7, 2019CirculationOpen Access

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

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Authors

MGMarios K. GeorgakisVascular / Pulmonary Vascular DGDipender GillPreventive Cardiology KRKristiina RannikmäeUniversity of California San Diego Medical Center

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Implication

Genetic analysis reveals elevated circulating MCP-1 increases stroke risk in predisposed individuals, suggesting targeting inflammatory chemokine pathways could reduce stroke incidence.

Key Points

To assess whether genetically determined circulating levels of cytokines, particularly MCP-1, are causally linked to the risk of stroke and specific stroke subtypes.
Evaluated the association between genetic predisposition to altered circulating cytokine levels and stroke outcomes.
Analyzed subtype-specific stroke risks, focusing on large-artery stroke and cardioembolic stroke.
Genetic predisposition to elevated circulating levels of MCP-1 is significantly associated with higher overall stroke risk.
Elevated MCP-1 levels are linked specifically to increased risks of large-artery stroke and cardioembolic stroke.

Cite This Study

Georgakis et al. (2019) studied this question.

synapsesocial.com/papers/69d9ba006b6d1f62eea3bfb9 https://doi.org/10.1161/circulationaha.118.035905

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Implication

Genetic analysis reveals elevated circulating MCP-1 increases stroke risk in predisposed individuals, suggesting targeting inflammatory chemokine pathways could reduce stroke incidence.

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

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