Why the study?
Does the severity of valve narrowing correlate with the pattern of LV adaptation and degree of hypertrophy in patients with moderate and severe aortic stenosis?
Does the severity of valve narrowing correlate with the pattern of LV adaptation and degree of hypertrophy in patients with moderate and severe aortic stenosis?
In patients with moderate to severe aortic stenosis, LV hypertrophy and adaptation patterns assessed by CMR do not closely correlate with valve narrowing severity, with asymmetric thickening being common.
LV patterns on CMR should not guide AS severity assessment; leaves open whether asymmetric hypertrophy adds independent prognostic value.
We have demonstrated that in patients with moderate and severe aortic stenosis, the pattern of LV adaption and degree of hypertrophy do not closely correlate with the severity of valve narrowing and that asymmetric patterns of wall thickening are common.
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Dweck et al. (2012) studied this question.
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