Uncoupling of glycolysis from glucose oxidation is identified as an early metabolic derangement that may drive the pathogenesis of HFpEF.
Hypothesis-generating for metabolic targets in HFpEF; requires human validation before any clinical consideration.
Overall, we show that increased glycolysis is the earliest energy metabolic change that occurs during HFpEF development. The resultant increased proton production from uncoupling of glycolysis and glucose oxidation may contribute to the development of HFpEF.
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Fillmore et al. (2018) studied this question.