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Experimental study demonstrates high-affinity binding of locked nucleic acids to complementary DNA and RNA, indicating enhanced thermal stability and hybridization selectivity.
A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.
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Singh et al. (1998) studied this question.
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