Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy

In preclinical models, radiolabeled FAP-2286 demonstrated high tumor uptake and retention, as well as potent efficacy in FAP-positive tumors. These results support clinical development of ⁶⁸Ga-FAP-2286 for imaging and ¹⁷⁷Lu-FAP-2286 for therapeutic use in a broad spectrum of FAP-positive tumors.