Randomized trial examines osteoclast adhesion through podosome assembly in cultured cells, indicating potential for signaling mechanisms.
The sealing zone of osteoclasts cultured on bone is made of structural units clearly related to individual podosomes. It differs from individual or clustered podosomes in the higher density and degree of inter-connectivity of its building blocks, thus forming a unique continuous functional structure connecting the cell to its extracellular milieu. Through this continuous structure, signals reporting on the substrate condition may be transmitted to the whole cell, modulating the cell response under physiological and pathological conditions.
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Luxenburg et al. (2007) studied this question.
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