Long-term persistence of transcriptionally active ‘defective’ HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy

Kanal Singh; Ven Natarajan; Robin Dewar; Adam Rupert; Yuden Badralmaa; Tracey Zhai; Nicole Winchester; Francesca Scrimieri; Mindy Smith; Ivery Davis; Perrine Lallemand; A Giglietti; Jack McNamara Hensien; Thomas Buerkert; Bruktawit Goshu; Catherine Rehm; Zonghui Hu; H. Clifford Lane; Hiromi Imamichi

doi:10.1097/qad.0000000000003667

Abstract

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These findings suggest a novel interplay between transcription and translation of 'defective' HIV-1 proviruses and the persistent immune activation seen in the setting of treated chronic HIV-1 infection.

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Cite This Study

Singh et al. (2023) studied this question.

synapsesocial.com/papers/69d9d9c8a1d151c65f6854aa https://doi.org/10.1097/qad.0000000000003667

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Long-term persistence of transcriptionally active ‘defective’ HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy

Abstract

Discussion

Cite This Study

Long-term persistence of transcriptionally active ‘defective’ HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy

Abstract

Discussion

Cite This Study

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