Why the study?
Does injection of human CRP and complement depletion affect infarct size in rats with acute myocardial infarction?
Does injection of human CRP and complement depletion affect infarct size in rats with acute myocardial infarction?
Human CRP and complement activation are major mediators of ischemic myocardial injury, identifying them as potential therapeutic targets in coronary heart disease.
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CRP-complement activation enlarges experimental infarcts; leaves open whether inhibition reduces human MI injury.
Griselli et al. (1999) studied this question.