Laboratory investigation demonstrates critical pH and stabilization requirements for [225Ac]Ac-DOTA-TATE radiolabeling, highlighting essential quality control measures for safe clinical use.
The quality of Ac-225 labeled DOTA-radiopharmaceuticals is highly dependent on the pH and stabilization (buffer/quencher). Within this research it is demonstrated that optimized quality control methods and accurate measurement of the radiolabeling kinetics are crucial to ensure safe implementation for patient treatment.
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Hooijman et al. (2025) studied this question.
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