What question did this study set out to answer?

To synthesize mechanistic evidence demonstrating that DNA replication stress links sustained proliferation to genomic instability and apoptosis evasion, supporting its classification as a cancer hallmark.

January 24, 2015Annual Review of Pathology Mechanisms of DiseaseOpen Access

DNA Replication Stress as a Hallmark of Cancer

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Authors

MMMorgane MacheretSophia Genetics (Switzerland)THThanos D. HalazonetisUniversity of Geneva

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Implication

Review uncovers how oncogene-induced DNA replication stress drives genomic instability and apoptosis avoidance in human cancers, highlighting replication stress as a fundamental cancer hallmark.

Key Points

To synthesize mechanistic evidence demonstrating that DNA replication stress links sustained proliferation to genomic instability and apoptosis evasion, supporting its classification as a cancer hallmark.
Synthesized molecular evidence detailing how oncogenes and tumor suppressor alterations that drive proliferation induce replication stress.
Evaluated models connecting replication stress to downstream patterns of genomic instability and the selective inactivation of apoptotic pathways such as TP53, ATM, and MDM2.
Oncogene-driven hyperproliferation reliably induces DNA replication stress, establishing a direct mechanistic bridge between cell cycle acceleration and genomic instability.
Replication stress exerts selective evolutionary pressure on pre-cancerous cells to bypass apoptosis by acquiring mutations in checkpoint genes including TP53, ATM, and MDM2.

Cite This Study

Macheret et al. (2015) studied this question.

synapsesocial.com/papers/69d9daf30f32475823a3c98c https://doi.org/10.1146/annurev-pathol-012414-040424

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Implication

Review uncovers how oncogene-induced DNA replication stress drives genomic instability and apoptosis avoidance in human cancers, highlighting replication stress as a fundamental cancer hallmark.

DNA Replication Stress as a Hallmark of Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

DNA Replication Stress as a Hallmark of Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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