Why the study?
Does sex affect the risk of developing Alzheimer Disease in individuals with the APOE ε3/ε4 genotype?
Does sex affect the risk of developing Alzheimer Disease in individuals with the APOE ε3/ε4 genotype?
Contrary to long-standing views, women with the APOE ε3/ε4 genotype have an increased risk of developing Alzheimer Disease at younger ages compared to men, though overall odds from age 55 to 85 are similar.
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Women with APOE ε3/ε4 may warrant earlier AD risk assessment; challenges prior equivalence assumptions but leaves open validation in prospective cohorts.
Neu et al. (2017) studied this question.
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