August 28, 2017JAMA Neurology647 citationsOpen Access
View Full PaperApolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease
Structured PICO
Does sex affect the risk of developing Alzheimer Disease in individuals with the APOE ε3/ε4 genotype?
P
Population
Men and women with the APOE ε3/ε4 genotype, aged 55 to 85 years
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Development of Alzheimer Disease (AD)hard clinical
Contrary to long-standing views, women with the APOE ε3/ε4 genotype have an increased risk of developing Alzheimer Disease at younger ages compared to men, though overall odds from age 55 to 85 are similar.
Abstract
Contrary to long-standing views, men and women with the APOE ε3/ε4 genotype have nearly the same odds of developing AD from age 55 to 85 years, but women have an increased risk at younger ages.