What question did this study set out to answer?

To determine whether longitudinal changes in clinical and physiologic variables over 6 and 12 months predict survival time in patients with idiopathic pulmonary fibrosis.

June 3, 2003American Journal of Respiratory and Critical Care Medicine

Changes in Clinical and Physiologic Variables Predict Survival in Idiopathic Pulmonary Fibrosis

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Authors

HCHarold R. CollardDélégation Paris 5 TKTalmadge E. KingUniversity of Arkansas at Little Rock BBBecki Bucher BartelsonDenver Health Medical Center

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Implication

Cohort study demonstrates longitudinal clinical and physiological changes predict survival in idiopathic pulmonary fibrosis, indicating dynamic monitoring improves prognostic accuracy.

Key Points

To determine whether longitudinal changes in clinical and physiologic variables over 6 and 12 months predict survival time in patients with idiopathic pulmonary fibrosis.
Evaluated serial changes in clinical symptoms and pulmonary function tests over time in 81 patients with biopsy-proven idiopathic pulmonary fibrosis.
Assessed dyspnea score, lung volumes, spirometry, diffusing capacity, and arterial blood gas parameters at 6 months (N=81) and 12 months (N=51) after baseline.
Six-month changes in dyspnea score, total lung capacity, thoracic gas volume, FVC, FEV1, diffusing capacity of carbon monoxide, PaO2, oxygen saturation, and alveolar-arterial oxygen gradient predicted survival after adjusting for baseline values.
Twelve-month changes in dyspnea score, total lung capacity, FVC, PaO2, oxygen saturation, and alveolar-arterial oxygen gradient remained predictive of survival after baseline adjustment.

Cite This Study

Collard et al. (2003) studied this question.

synapsesocial.com/papers/69d9e1645e5bcb4e3b8382de https://doi.org/10.1164/rccm.200211-1311oc

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Implication

Cohort study demonstrates longitudinal clinical and physiological changes predict survival in idiopathic pulmonary fibrosis, indicating dynamic monitoring improves prognostic accuracy.

Changes in Clinical and Physiologic Variables Predict Survival in Idiopathic Pulmonary Fibrosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Changes in Clinical and Physiologic Variables Predict Survival in Idiopathic Pulmonary Fibrosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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