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April 11, 20260 citations

Tranexamic Acid for Acute Bleeding in Severely Traumatized Patients: Mortality, Neurological Outcomes, and Thromboembolic Risk.

HLHeiko Lier MMMarc Maegele BHB. Hossfeld

Key Points

To assess the impact of tranexamic acid on mortality, neurological outcomes, and thromboembolic risk in severely traumatized patients with acute bleeding.
Administered tranexamic acid (TXA) in a single dose of 1-2 g before hospital arrival.
Focused on trauma patients experiencing life-threatening hemorrhage.
Evaluated both mortality and neurological outcomes post-treatment.
TXA administration was associated with improved survival rates in trauma patients.
Neurological outcomes did not significantly worsen with TXA use.
Thromboembolic events remained low despite TXA use.

Abstract

For trauma patients with life-threatening hemorrhage, especially those in hemorrhagic shock, it is recommended that TXA be given as early as possible (before arrival in the hospital) in a single dose of 1-2 g (15-30 mg/kg body weight BW). When this is done, the benefit appears to be greater than the thromboembolic risk.

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Lier et al. (Fri,) studied this question.

synapsesocial.com/papers/69d9e50778050d08c1b75486 https://doi.org/https://doi.org/10.3238/arztebl.m2026.0046

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