What question did this study set out to answer?

To evaluate the impact of tranexamic acid administration on mortality, coagulopathy, blood product utilization, and thromboembolic complications in combat-injured patients requiring blood transfusions.

October 18, 2011Archives of Surgery

Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study

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To evaluate the impact of tranexamic acid administration on mortality, coagulopathy, blood product utilization, and thromboembolic complications in combat-injured patients requiring blood transfusions.
Retrospective observational study of 896 consecutive combat casualties receiving at least 1 unit of packed red blood cells (293 received tranexamic acid) at a Role 3 surgical hospital in southern Afghanistan.
Identified patients from prospectively collected UK and US trauma registries and analyzed a predefined subgroup receiving massive transfusion (≥10 units of packed red blood cells) using regression models.
The tranexamic acid group had lower unadjusted mortality than the no-tranexamic acid group (17.4% vs 23.9%; P = .03), despite higher baseline injury severity (mean Injury Severity Score 25.2 vs 22.5; P < .001).
Among patients receiving massive transfusions, tranexamic acid reduced mortality (14.4% vs 28.1%; P = .004), independently associated with survival (OR = 7.228; 95% CI, 3.016–17.322) and reduced coagulopathy (P = .003).

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Implication

Retrospective observational study reveals improved survival with tranexamic acid in combat trauma, indicating strong clinical benefit during massive transfusion.

Cite This Study

Jonathan J. Morrison (2011) studied this question.

synapsesocial.com/papers/6a6db29d5d37378ac1dba8b5 https://doi.org/10.1001/archsurg.2011.287

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Implication

Retrospective observational study reveals improved survival with tranexamic acid in combat trauma, indicating strong clinical benefit during massive transfusion.

Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study

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Discussion

Implication

Cite This Study

Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study

Key Points

Discussion

Implication

Cite This Study

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