Reirradiation treatment effects in the clinic (ReTEC) proposal – proof of concept based on spinal cord dose tolerance for reirradiation with stereotactic body radiotherapy

Jimm Grimm; A. Mahadevan; Olusola Obayomi‐Davies; Scott G. Soltys; Arjun Sahgal; Kristin J. Redmond; Michael T. Milano; Wolfgang A. Tomé; Kenneth Brooks; Scott Dodd; John Austin Vargo; Gopal Subedi; Jinyu Xue; Bisher Ebid; Felix Ehret; Byung‐Han Andrew Rhieu; Christoph Fürweger; Rachel J Grimm; Alexander Muacevic; Vitali Moiseenko; Shalom Kalnicki; Mark P. McLaughlin; Lawrence R. Kleinberg; John R. Adler; Iris C. Gibbs

doi:10.1002/acm2.70557

Key Points

The aim is to evaluate the effects of reirradiation treatment on spinal cord dose tolerance using a new model.
Developing composite plans for different Dmax locations for each treatment course.
Analyzing existing standard guidelines and their applicability to new findings under the ReTEC project.
Creating a proof-of-concept Dmax model to assess dosing for reirradiation.
The proposed Dmax model offers insights into dose distributions for the spinal cord.
Current guidelines may need adjustment based on further analysis under the ReTEC initiative.

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Implication

Proof-of-concept investigates dose tolerance in spinal cord during reirradiation, suggesting future standards.

Abstract

Due to limited data, we recommend remaining within current standard guidelines until more comprehensive analyses, optimally under the ReTEC initiative, refute or validate these estimates. ReTEC would require composite plans accounting for differing Dmax locations in each course. Nevertheless, this proof-of-concept Dmax model provides insight and serves as a basis to propose ReTEC.

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Cite This Study

Grimm et al. (2026) studied this question.

synapsesocial.com/papers/69d9e52b78050d08c1b755c6 https://doi.org/10.1002/acm2.70557

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Reirradiation treatment effects in the clinic (ReTEC) proposal – proof of concept based on spinal cord dose tolerance for reirradiation with stereotactic body radiotherapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Reirradiation treatment effects in the clinic (ReTEC) proposal – proof of concept based on spinal cord dose tolerance for reirradiation with stereotactic body radiotherapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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