Circ-PVT1 derived protein enhances tumorigenesis in colorectal cancer, suggesting a link to worse outcomes.
Circ-PVT1 is upregulated in CRC patients and encoded a novel protein: PVT1-104aa. PVT1-104aa promotes CRC progression and predicts worse prognosis. PVT1-104aa enhance Myc expression through inhibition of Myc ubiquitination. PVT1-104aa regulate PD-L1 expression of CRC cells and modulate T cells infiltration in vivo.
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Ma et al. (2026) studied this question.
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