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Analytical framework enhances AAV aggregation testing, improving product development and stability evaluation.
No single analytical method captures all AAV aggregation species across all conditions. A purpose-driven framework for selecting SEC-UV, SEC-FLD, DLS, and A4F – what each method detects, where each fails, and how to combine them for release testing, stability studies, and forced degradation.
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Zhao et al. (2026) studied this question.
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