What question did this study set out to answer?

To examine hydrogen production in a patient with fructose malabsorption following hydrogen breath testing.

April 11, 2026Journal of Neurogastroenterology and Motility1 citationsOpen Access

Substrate-dependent Differences of Colonic Hydrogen Production in a Patient With Fructose Malabsorption

Key Points

To examine hydrogen production in a patient with fructose malabsorption following hydrogen breath testing.
Conducted hydrogen/methane breath testing using different substrates: lactulose, glucose, lactose, and sorbitol.
Monitored hydrogen production profiles pre- and post-ingestion of substrates.
Analyzed breath test results for flatline hydrogen production.
The patient exhibited abnormal fructose test results with no hydrogen production.
Flatline H 2 profiles were noted during lactulose, glucose, and other substrate tests.
Indicates potential variance in gut response based on the type of carbohydrate ingested.

Abstract

Hydrogen (H 2 )/methane (CH 4 ) breath testing (HMBT) is the most widely utilized diagnostic modality for the diagnosis of many common gastrointestinal conditions including small intestinal bacterial overgrowth (SIBO), intestinal methanogen overgrowth (IMO), irritable bowel syndrome-like symptoms, and carbohydrate malabsorption. 122]3 Often, in interpreting the lactulose HMBT, the term "hydrogen nonproducer" is used for a H 2 breath profile that is "flatline". 4,5Here we report on a patient with abnormal fructose HMBT results that failed to produce H 2 upon lactulose, glucose, lactose, and sorbitol HMBT.

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